Progression of fibrosis involves interstitial hypercellularity, matrix accumulation, and atrophy
of epithelial structures, resulting in loss of normal function and ultimately organ failure. There …

Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease
(NAFLD). Recent studies identify mechanisms common to both diseases linked through an …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease
(PD), but the underlying pathophysiological mechanisms and the normal function of this …

mRNA translation plays a central role in the regulation of gene expression and represents
the most energy consuming process in mammalian cells. Accordingly, dysregulation of …

Hyperglycemia induces a wide array of signaling pathways in the kidney that lead to
hypertrophy and matrix expansion, eventually culminating in progressive kidney failure …

Abstract Significance: Hydrogen sulfide (H2S) has only recently gained recognition for its
physiological effects. It is synthesized widely in the mammalian tissues and regulates …

Despite the advances in immunosuppression, renal allograft attrition over time remains
unabated due to chronic allograft dysfunction (CAD) with interstitial fibrosis (IF) and tubular …

Increased accumulation of extracellular matrix proteins and hypertrophy induced by
transforming growth factor-β1 (TGF-β) in renal mesangial cells (MC) are hallmark features of …

Oxidative stress has been linked to the pathogenesis of diabetic nephropathy, a
complication of diabetes in the kidney. NADPH oxidases of the Nox family are a major …

Hydrogen sulfide, a signaling gas, affects several cell functions. We hypothesized that
hydrogen sulfide modulates high glucose (30 mm) stimulation of matrix protein synthesis in …