Mechanisms of DNA-reactive and epigenetic chemical carcinogens: applications to carcinogenicity testing and risk assessment

T Kobets, MJ Iatropoulos, GM Williams - Toxicology Research, 2019 - academic.oup.com
Chemicals with carcinogenic activity in either animals or humans produce increases in
neoplasia through diverse mechanisms. One mechanism is reaction with nuclear DNA …

Genotoxic and epigenotoxic alterations in the lung and liver of mice induced by acrylamide: a 28 day drinking water study

A de Conti, V Tryndyak, LS VonTungeln… - Chemical research in …, 2019 - ACS Publications
Acrylamide has been classified as a “Group 2A carcinogen”(probably carcinogenic to
humans) by the International Agency for Research on Cancer. The carcinogenicity of …

Effect of aflatoxin B1, benzo [a] pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells

V Tryndyak, I Kindrat, K Dreval, MI Churchwell… - Food and Chemical …, 2018 - Elsevier
The increasing number of man-made chemicals in the environment that may pose a
carcinogenic risk highlights the need for developing reliable time-and cost-effective …

Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis

R Terranova, A Vitobello, ADR Espinola… - Current Opinion in …, 2017 - Elsevier
Determining the human relevance of structurally and functionally distinct non-genotoxic
carcinogenic compounds that induce a diverse range of tissue-, gender-, strain-and species …

Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein

S Saussenthaler, M Ouni, C Baumeier… - The Journal of …, 2019 - Elsevier
Abstract Dipeptidyl peptidase 4 (DPP4) is known to be elevated in metabolic disturbances
such as obesity, type 2 diabetes and fatty liver disease. Lowering DPP4 concentration by …

Application of duplex sequencing to evaluate mutagenicity of aristolochic acid and methapyrilene in Fisher 344 rats

S Sahib, J Yan, T Chen - Food and Chemical Toxicology, 2024 - Elsevier
Duplex sequencing (DS) is an error-corrected next-generation sequencing (NGS) method
that can overcome notorious high error rate from the process of NGS and detect ultralow …

In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism

A Braeuning, A Oberemm, T Heise… - Archives of …, 2019 - Springer
The antihistaminic drug methapyrilene was withdrawn from the market in 1979 because of
hepatocarcinogenicity in rats. Since then, the drug has been used as a model hepatotoxin …

Chemical carcinogen exposure, DNA damage, and epigenetic alterations

K Dreval, IP Pogribny - Carcinogens, DNA damage and cancer risk …, 2019 - World Scientific
The risk of the cancer development in humans is determined by the interaction of two main
cancer-causing factors, genetics and carcinogen exposure. It is well-established that …

[图书][B] Assessing the role of epigenetic factors in chromosome instability following compound exposure

RSS Beck - 2020 - search.proquest.com
The maintenance of the epigenome is critical for cell survival, with its dysregulation resulting
in a multitude of disease states including rheumatoid arthritis, multiple sclerosis and …

Mechanisms of Action of Carcinogenic Chemicals Including Occupational Carcinogens

T Kobets, GM Williams - Patty's Toxicology, 2001 - Wiley Online Library
This chapter provides an overview of the diverse mechanisms, which are involved in the
induction of neoplasia produced by chemical carcinogens, including occupational …