The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

GATA transcriptional factors are zinc finger DNA binding proteins that regulate transcription
during development and cell differentiation. The 3 important GATA transcription factors …

The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge in …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

The syndrome of monocytopenia, B-cell and NK-cell lymphopenia, and mycobacterial,
fungal, and viral infections is associated with myelodysplasia, cytogenetic abnormalities …

The study of gene regulation is dominated by a focus on the control of gene activation or
increase in the level of expression. Just as critical is the process of gene repression or …

The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …

Enhancers are the primary determinants of cell identity, but the regulatory components
controlling enhancer turnover during lineage commitment remain largely unknown. Here we …

Epithelial–mesenchymal transition (EMT) is a highly conserved process defined by the loss
of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its …