T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the
cytoplasmic double-stranded DNA and activates the antiviral response. However, the …

Immunological self-tolerance is established in the thymus by the expression of virtually all
self-antigens, including tissue-restricted antigens (TRAs) and cell-type–restricted antigens …

Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …

Protein arginine transferase 5 (PRMT5) has been implicated as an important modulator of
tumorigenesis as it promotes tumor cell proliferation, invasion, and metastasis. Studies have …