Tumor suppressor p53 maintains genome stability by regulating diverse cellular functions
including cell cycle arrest, apoptosis, senescence and metabolic homeostasis. Mutations in …

The transcription factor nuclear factorkappa B (NF‐KB) is a crucial regulator of many
physiological and patho‐physiological processes, including control of the adaptive and …

Although estrogen receptors (ERs) recognize 15-bp palindromic estrogen response
elements (EREs) with maximal affinity in vitro, few near-consensus sequences have been …

The G protein–coupled receptor GPR30 binds 17β-estradiol (E2) yet differs from classic
estrogen receptors (ERα and ERβ). GPR30 can mediate E2-induced nongenomic signaling …

Cancers of the breast and other tissues arise from aberrant decision-making by cells
regarding their survival or death, proliferation or quiescence, damage repair or bypass …

Mutations of the ubiquitin ligase parkin account for most autosomal recessive forms of
juvenile Parkinson's disease (AR-JP). Several studies have suggested that parkin …

dimethylhydrazine (DMH) is a member in the class of hydrazines, strong DNA alkylating
agent, naturally present in cycads. DMH is widely used as a carcinogen to induce colon …

Glucocorticoids and estrogens regulate a number of vital physiological processes. We
developed a model breast cancer cell line, MCF-7 M, to examine potential mechanisms by …

Estrogen receptor-α (ERα) promotes proliferation of breast cancer cells, whereas tumor
suppressor protein p53 impedes proliferation of cells with genomic damage. Whether there …

The Notch pathway plays a key role in the development and is increasingly recognized for
its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its …