Diabetes mellitus is a major public health issue that affected 537 million people worldwide in
2021, a number that is only expected to increase in the upcoming decade. Diabetes is a …

Significance: The prevalence of obesity and cardiometabolic phenotypes is alarmingly
increasing across the globe and is associated with atherosclerotic vascular complications …

Aims/hypothesis Myeloid-derived growth factor (MYDGF), mainly secreted by bone marrow-
derived cells, has been known to promote glucagon-like peptide-1 production and improve …

Background Status epilepticus (SE) as a severe neurodegenerative disease, greatly
negatively affects people's health, and there is an urgent need for innovative treatments. The …

Dipeptidyl peptidase-4 (DPP-4) inhibitors have been considered as incretin-based agents
that signal through GLP-1R. Our high-throughput RNA sequencing (RNA-seq) and …

Background Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. It is unclear whether inhibition of sodium glucose cotransporter 2 …

Oxidative balance plays a pivotal role in physiological homeostasis, and many diseases,
particularly age-related conditions, are closely associated with oxidative imbalance. While …

In this study, we investigate the effect of neuregulin 4 (NRG4) on podocyte damage in a
mouse model of diabetic nephropathy (DN) and we elucidate the underlying molecular …

Abstract Neuregulin 4 (Nrg4) is a brown fat-enriched endocrine factor that exerts beneficial
metabolic effects on insulin resistance and hepatic steatosis. Autophagy is a mechanism that …

Abstract Sodium-glucose transporter-2 inhibitors (SGLT-2i) and glucagon-like peptide 1
(GLP-1) receptor agonists are newer antidiabetic drug classes, which were recently shown …