Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

A phosphatidyllnosltol(PI) kinase activity associated with certain protein tyrosine kinases
important in cell proliferation phosphorylates the 3'hydroxyl position of PI to produce …

The endogenous cannabinoid system has been shown to play a crucial role in controlling
neuronal excitability and synaptic transmission. In this study we investigated the effects of a …

MANY hormones, neurotransmitters and growth factors, on binding to G protein-coupled
receptors or receptors possessing tyrosine kinase activity, increase intracellular levels of the …

Introduction Polyamines (putrescine, spermidine and spermine) are ubiquitous polycationic
metabolites in prokaryotic and eukaryotic cells. Their roles in the regulation of major …

PDGF binding to its receptor promotes the association with and stimulates the
phosphorylation of PLCqi at tyrosine and serine residues. Also, PDGF induces an increase …

The physiological effects of many extracellular neurotransmitters, hormones, growth factors,
and other stimuli are mediated by receptor-promoted activation of phospholipase C (PLC) …

Purified Ml muscarlnlc cholinergic receptor and G,, M were coreconstituted in llpid vesicles.
Addition of purifled phospholipase C-p1 (PLC-pl) further stimulated the receptor-promoted …

Inositol phospholipid-specific phospholipase C is the enzyme that generates
phosphoinositide-derived messenger molecules. Mammalian cells contain at least five …