From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

EH Pilkington, EJA Suys, NL Trevaskis, AK Wheatley… - Acta biomaterialia, 2021 - Elsevier
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …

Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease

Z Zhang, R Dalan, Z Hu, JW Wang… - Advanced …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation

JW Myerson, PN Patel, KM Rubey, ME Zamora… - Nature …, 2022 - nature.com
This study shows that the supramolecular arrangement of proteins in nanoparticle structures
predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We …

[HTML][HTML] Polymeric micellar systems—a special emphasis on “smart” drug delivery

I Negut, B Bita - Pharmaceutics, 2023 - mdpi.com
Concurrent developments in anticancer nanotechnological treatments have been observed
as the burden of cancer increases every year. The 21st century has seen a transformation in …

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

VT Cong, JL Houng, M Kavallaris, X Chen… - Chemical Society …, 2022 - pubs.rsc.org
Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …

Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)

H Parhiz, JS Brenner, PN Patel, TE Papp… - Journal of Controlled …, 2022 - Elsevier
Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has
successfully paved the way for the highest clinical efficacy data from next-generation …

Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale

M Cooley, A Sarode, M Hoore, DA Fedosov… - Nanoscale, 2018 - pubs.rsc.org
Intravascular drug delivery technologies majorly utilize spherical nanoparticles as carrier
vehicles. Their targets are often at the blood vessel wall or in the tissue beyond the wall …

Influence of nanomedicine mechanical properties on tumor targeting delivery

Z Li, C Xiao, T Yong, Z Li, L Gan, X Yang - Chemical Society Reviews, 2020 - pubs.rsc.org
Modulating nanomedicine mechanical properties for enhanced drug delivery to tumors has
attracted increasing attention in the past few decades. In this tutorial review, we analyze the …

[HTML][HTML] Chicken egg white: Hatching of a new old biomaterial

S Jalili-Firoozinezhad, M Filippi, F Mohabatpour… - Materials Today, 2020 - Elsevier
Chicken egg white is an abundant, inexpensive and natural source of important proteins
such as ovalbumin and lysozyme. Thanks to its bioactivity, easy handling, anti-bacterial …

Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier

OA Marcos-Contreras, CF Greineder… - Proceedings of the …, 2020 - National Acad Sciences
Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …