Human NK cell development: one road or many?
F Cichocki, B Grzywacz, JS Miller - Frontiers in immunology, 2019 - frontiersin.org
CD3− CD56+ NK cells develop from CD34+ hematopoietic progenitors (HPCs) in vivo, and
this process can be recapitulated in vitro. The prevailing model is that human NK cell …
this process can be recapitulated in vitro. The prevailing model is that human NK cell …
The prenatal origins of cancer
GM Marshall, DR Carter, BB Cheung, T Liu… - Nature Reviews …, 2014 - nature.com
The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …
cells has a long history. Recent research has strengthened the links between driver …
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
INTRODUCTION The hematopoietic road map is a compilation of the various lineage
differentiation routes that a stem cell takes to make blood. This program produces greater …
differentiation routes that a stem cell takes to make blood. This program produces greater …
[HTML][HTML] Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells
R Yamamoto, Y Morita, J Ooehara, S Hamanaka… - Cell, 2013 - cell.com
Consensus holds that hematopoietic stem cells (HSCs) give rise to multipotent progenitors
(MPPs) of reduced self-renewal potential and that MPPs eventually produce lineage …
(MPPs) of reduced self-renewal potential and that MPPs eventually produce lineage …
[HTML][HTML] Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia
N Goardon, E Marchi, A Atzberger, L Quek, A Schuh… - Cancer cell, 2011 - cell.com
The relationships between normal and leukemic stem/progenitor cells are unclear. We show
that in∼ 80% of primary human CD34+ acute myeloid leukemia (AML), two expanded …
that in∼ 80% of primary human CD34+ acute myeloid leukemia (AML), two expanded …
Mechanisms of T cell development and transformation
U Koch, F Radtke - Annual review of cell and developmental …, 2011 - annualreviews.org
T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …
involve a complex variety of interactions with nonlymphoid cell products and receptors …
[HTML][HTML] Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
The major myeloid blood cell lineages are generated from hematopoietic stem cells by
differentiation through a series of increasingly committed progenitor cells. Precise …
differentiation through a series of increasingly committed progenitor cells. Precise …
Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
M Kondo - Immunological reviews, 2010 - Wiley Online Library
Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a
series of lineage restriction steps that results in the progressive loss of differentiation …
series of lineage restriction steps that results in the progressive loss of differentiation …
Transcription factors in myeloid development: balancing differentiation with transformation
F Rosenbauer, DG Tenen - Nature Reviews Immunology, 2007 - nature.com
In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …
the myeloid lineage. Transcription factors have been shown to be key determinants in the …
Launching the T-cell-lineage developmental programme
EV Rothenberg, JE Moore, MA Yui - Nature Reviews Immunology, 2008 - nature.com
Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …
process in which they gradually acquire T-cell characteristics while shedding their legacy of …