Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?

B Sharma, V Kumar - Journal of medicinal chemistry, 2021 - ACS Publications
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Synthesis and pharmacological properties of chalcones: a review

SL Gaonkar, UN Vignesh - Research on chemical intermediates, 2017 - Springer
Chalcones and their analogs have been an area of great interest in recent years. Numerous
research papers have been published, and chalcones continue to show promise for new …

Ferrocene derivatives as anti-infective agents

BS Ludwig, JDG Correia, FE Kühn - Coordination Chemistry Reviews, 2019 - Elsevier
Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Perspectives of medicinally privileged chalcone based metal coordination compounds for biomedical applications

DK Mahapatra, SK Bharti, V Asati, SK Singh - European journal of …, 2019 - Elsevier
Recent clinical reports have highlighted the increasing occurrence of drug resistance of
known therapeutics. Particularly, antibiotic resistant microorganisms and multidrug …

Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial

D Dive, C Biot - ChemMedChem, 2007 - pmc.ncbi.nlm.nih.gov
A convenient approach to antimalarial drug discovery is the use of the organic scaffold of a
known antimalarial drug and an organometallic moiety to alter its unwanted properties …

Metalloantimalarials

PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …

α-Alkylation of ketones with primary alcohols catalyzed by a Cp* Ir complex bearing a functional bipyridonate ligand

F Li, J Ma, N Wang - The Journal of Organic Chemistry, 2014 - ACS Publications
A Cp* Ir complex bearing a functional bipyridonate ligand was found to be a highly effective
and versatile catalyst for the α-alkylation of ketones with primary alcohols under extremely …

Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity

V Tomar, G Bhattacharjee, S Rajakumar… - European journal of …, 2010 - Elsevier
A series of novel chalcones bearing acridine moiety attached to the amino group in their ring
A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction …

Synthesis of a-Alkylated Ketones via Tandem Acceptorless Dehydrogenation/a-Alkylation from Secondary and Primary Alcohols Catalyzed by Metal–Ligand Bifunctional Iridium …

R Wang, J Ma, F Li - The Journal of Organic Chemistry, 2015 - ACS Publications
A new strategy for the synthesis of α-alkylated ketones via tandem acceptorless
dehydrogenation/α-alkylation from secondary and primary alcohols was proposed and …

Ferrocene functionalized endocrine modulators as anticancer agents

EA Hillard, A Vessieres, G Jaouen - Medicinal Organometallic Chemistry, 2010 - Springer
We present here some of our studies on the synthesis and behaviour of ferrocenyl selective
endocrine receptor modulators against cancer cells, particularly breast and prostate …