CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery
Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …
or modulating gene expression. The clustered regularly interspaced short palindromic …
Energy transfer with semiconductor quantum dot bioconjugates: a versatile platform for biosensing, energy harvesting, and other developing applications
Luminescent semiconductor quantum dots (QDs) are one of the more popular nanomaterials
currently utilized within biological applications. However, what is not widely appreciated is …
currently utilized within biological applications. However, what is not widely appreciated is …
Microfluidic nanomaterials: From synthesis to biomedical applications
Microfluidic platforms gain popularity in biomedical research due to their attractive inherent
features, especially in nanomaterials synthesis. This review critically evaluates the current …
features, especially in nanomaterials synthesis. This review critically evaluates the current …
Evaluation of novel cationic gene based liposomes with cyclodextrin prepared by thin film hydration and microfluidic systems
H Elsana, TOB Olusanya, J Carr-Wilkinson, S Darby… - Scientific reports, 2019 - nature.com
In gene delivery, non-viral vectors have become the preferred carrier system for DNA
delivery. They can overcome major viral issues such as immunogenicity and mutagenicity …
delivery. They can overcome major viral issues such as immunogenicity and mutagenicity …
Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system
J O'Keeffe Ahern, I Lara-Sáez, D Zhou, R Murillas… - Gene therapy, 2022 - nature.com
Recent advances in molecular biology have led to the CRISPR revolution, but the lack of an
efficient and safe delivery system into cells and tissues continues to hinder clinical …
efficient and safe delivery system into cells and tissues continues to hinder clinical …
Droplet microfluidics for synthetic biology
Synthetic biology is an interdisciplinary field that aims to engineer biological systems for
useful purposes. Organism engineering often requires the optimization of individual genes …
useful purposes. Organism engineering often requires the optimization of individual genes …
In situ bone tissue engineering using gene delivery nanocomplexes
Gene delivery offers promising outcomes for functional recovery or regeneration of lost
tissues at cellular and tissue levels. However, more efficient carriers are needed to safely …
tissues at cellular and tissue levels. However, more efficient carriers are needed to safely …
Biomaterials meet microfluidics: from synthesis technologies to biological applications
J Ma, Y Wang, J Liu - Micromachines, 2017 - mdpi.com
Microfluidics is characterized by laminar flow at micro-scale dimension, high surface to
volume ratio, and markedly improved heat/mass transfer. In addition, together with …
volume ratio, and markedly improved heat/mass transfer. In addition, together with …
Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles
Intracellular nucleic acid delivery has the potential to treat many genetically-based diseases,
however, gene delivery safety and efficacy remains a challenging obstacle. One promising …
however, gene delivery safety and efficacy remains a challenging obstacle. One promising …
Bioreducible polycations in nucleic acid delivery: past, present, and future trends
D Oupický, J Li - Macromolecular bioscience, 2014 - Wiley Online Library
Polycations that are degradable by reduction of disulfide bonds are developed for
applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of …
applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of …