The challenges of drug development in pediatric, pregnant and geriatric populations are a
worldwide concern shared by regulatory authorities, pharmaceutical companies, and …

Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide.
Finding rapid and reliable methods for early recognition and diagnosis of bacterial infections …

Background and aim: Vancomycin, a glycopeptide antimicrobial drug. PPK has problems
such as difficulty in accurately reflecting inter-individual differences, and the PPK model may …

Background Accurate prediction of the optimal dose for β-lactam antibiotics in neonatal
sepsis is challenging. We aimed to evaluate whether a reliable clinical decision support …

Daptomycin is a concentration-dependent lipopeptide antibiotic for which exposure/effect
relationships have been shown. Machine learning (ML) algorithms, developed to predict the …

Aims Although there are various model‐based approaches to individualized vancomycin
(VCM) administration, few have been reported for adult patients with periprosthetic joint …

Background Vancomycin trough concentration is closely associated with clinical efficacy and
toxicity. Predicting vancomycin trough concentrations in pediatric patients is challenging due …

Introduction Peritonitis is a serious complication of peritoneal dialysis (PD), in which
insufficient control of antibacterial drug concentrations poses a significant risk for poor …

Off-label drug use is very common in neonatal and pediatric patients (Tang BH et al., 2023).
The pediatric population shows major changes in the way they can handle drugs due to their …