Heat shock proteins (HSPs) are a large group of chaperones found in most eukaryotes and
bacteria. They are responsible for the correct protein folding, protection of the cell against …

The function of sperm is to safely transport the haploid paternal genome to the egg
containing the maternal genome. The subsequent fertilization leads to transmission of a new …

The human heat shock protein 70 (Hsp70) family contains at least eight homologous
chaperone proteins. Endoplasmatic reticulum and mitochondria have their specific Hsp70 …

Spermatogenesis, a study of germ cell development, is a long, orderly, and well‐defined
process occurring in seminiferous tubules of the testis. It is a temporal event whereby …

BACKGROUND Asthenozoospermia is one of the most common findings present in infertile
males, but its aetiology remains unknown in most cases. Present proteomic tools now offer …

Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of
the nutrient-sensing mTOR gerogene. mTOR-driven aging can be triggered or accelerated …

A common defect encountered in the spermatozoa of male infertility patients is an idiopathic
failure of sperm–egg recognition. In order to resolve the molecular basis of this condition we …

The 70-kDa heat shock proteins (Hsp70) are chaperones with central roles in processes that
involve polypeptide remodeling events. Hsp70 proteins consist of two major functional …

BACKGROUND Spermatogenesis culminates in production of one of the most highly
differentiated cells in biology, the spermatozoon. The gametes that emerge from the testes …

During human spermiogenesis, the elongated spermatids undergo a plasma membrane
remodeling step that facilitates formation of the zona pellucida and hyaluronic acid (HA) …