[HTML][HTML] Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease

B Zingales, DC Bartholomeu - Memórias do instituto oswaldo cruz, 2022 - SciELO Brasil
Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …

[HTML][HTML] What do you need to know before studying Chagas disease? A beginner's guide

JA De Fuentes-Vicente, NG Santos-Hernández… - Tropical Medicine and …, 2023 - mdpi.com
Chagas disease is one of the most important tropical infections in the world and mainly
affects poor people. The causative agent is the hemoflagellate protozoan Trypanosoma …

[HTML][HTML] Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications

A Herreros-Cabello, F Callejas-Hernández, N Gironès… - Genes, 2020 - mdpi.com
Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

[HTML][HTML] Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show

O Campetella, CA Buscaglia, J Mucci… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Many important pathogen-host interactions rely on highly specific carbohydrate binding
events. In the case of the protozoan Trypanosoma cruzi, the causative agent of Chagas …

[HTML][HTML] Mucins and pathogenic mucin-like molecules are immunomodulators during infection and targets for diagnostics and vaccines

S Pinzón Martín, PH Seeberger, D Varón Silva - Frontiers in chemistry, 2019 - frontiersin.org
Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell
surface of mammals and other organisms. These glycoproteins are highly diverse in the …

An update on the knowledge of parasite–vector interactions of Chagas Disease

GA Schaub - Research and reports in tropical medicine, 2021 - Taylor & Francis
This review focusses on the interactions between the etiologic agent of Chagas disease,
Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal …

[HTML][HTML] A sticky situation: When trypanosomatids attach to insect tissues

ML Povelones, NA Holmes, M Povelones - PLoS Pathogens, 2023 - journals.plos.org
Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect …

[HTML][HTML] Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients

G Romer, LA Bracco, AD Ricci, V Balouz… - PLOS Neglected …, 2023 - journals.plos.org
Background Trypanosoma cruzi, the agent of Chagas disease, displays a highly structured
population, with multiple strains that can be grouped into 6–7 evolutionary lineages showing …

Interaction of triatomines with their bacterial microbiota and trypanosomes

AA Guarneri, GA Schaub - Triatominae-The Biology of Chagas Disease …, 2021 - Springer
In this book chapter, we discuss the interactions between triatomines, two heteroxenous
trypanosomatids—Trypanosoma cruzi, the etiologic agent of Chagas disease, and …

[HTML][HTML] The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose

ME Giorgi, RM Lederkremer - Molecules, 2020 - mdpi.com
Trypanosoma cruzi, the protozoa that causes Chagas disease in humans, is transmitted by
insects from the Reduviidae family. The parasite has developed the ability to change the …