Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …

Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction
in Parkinson's disease, which makes cell replacement a promising therapeutic approach …

Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected
source for cell-based therapies for Parkinson's disease (PD). The regulatory criteria for the …

The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Differentiation of human pluripotent stem cells to small brain-like structures known as brain
organoids offers an unprecedented opportunity to model human brain development and …

Mutations in the E3 ubiquitin ligase parkin are the most common cause of early-onset
Parkinson's disease (PD). Although parkin modulates mitochondrial and endolysosomal …

Reactive astrocytes are strongly induced by central nervous system (CNS) injury and
disease, but their role is poorly understood. Here we show that a subtype of reactive …

We report the implantation of patient-derived midbrain dopaminergic progenitor cells,
differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient …