In the last few years, the discovery of lysine and arginine methylation in histones and other
proteins and the enzymes that carry out these posttranslational modifications has added a …

▪ Abstract With genome sequencing nearing completion for the model organisms used in
biomedical research, there is a rapidly growing appreciation that proteomics, the study of …

PRMT1 is the predominant type I protein arginine methyltransferase in mammals and highly
conserved among all eukaryotes. It is essential for early postimplantation development in …

Protein arginine methylation is a common post-translational modification that has been
implicated in signal transduction, RNA processing, transcriptional regulation, and DNA …

Protein arginine methyltransferases (PRMTs) catalyze the methyl transfer to the arginine
residues of protein substrates and are classified into three major types based on the final …

The impact of protein arginine methylation on the regulation of immune functions is virtually
unknown. Here, we apply a novel method—isomethionine methyl-SILAC—coupled with …

Introduction 3. Role of histone arginine methylation in gene regulation 3.1. Protein arginine
methyltransferases catalyze histone arginine methylation 3.2. Transcriptional activation …

PRMT1 is the predominant member of a family of protein arginine methyltransferases
(PRMTs) that have been implicated in various cellular processes, including transcription …

Spinal muscular atrophy is an autosomal-recessive neuromuscular disease caused by
disruption of the survival of motor neuron (SMN) gene, which promotes cytoplasmic …

Erythropoiesis requires tight control of expansion, maturation, and survival of erythroid
progenitors. Because activation of phosphatidylinositol-3-kinase (PI3K) is required for …