Clinical update on head and neck cancer: molecular biology and ongoing challenges
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …
Temozolomide-associated hypermutation in gliomas
Low-grade gliomas cause considerable morbidity and most will recur after initial therapy. At
recurrence, low-grade gliomas can undergo transformation to high-grade gliomas (grade III …
recurrence, low-grade gliomas can undergo transformation to high-grade gliomas (grade III …
Head and neck cancer: Current challenges and future perspectives
GR Bhat, RG Hyole, J Li - Advances in Cancer Research, 2021 - Elsevier
Head and neck cancers are a heterogeneous, aggressive and genetically complex
collection of malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, larynx …
collection of malignancies of the oral cavity, nasopharynx, oropharynx, hypopharynx, larynx …
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
J Felsberg, N Thon, S Eigenbrod… - … journal of cancer, 2011 - Wiley Online Library
Epigenetic silencing of the O6‐methylguanine‐DNA methyltransferase (MGMT) gene
promoter is associated with prolonged survival in glioblastoma patients treated with …
promoter is associated with prolonged survival in glioblastoma patients treated with …
Targeting DNA double-strand break repair pathways to improve radiotherapy response
M Toulany - Genes, 2019 - mdpi.com
More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …
Chronic ionizing radiation of plants: An evolutionary factor from direct damage to non-target effects
In present times, the levels of ionizing radiation (IR) on the surface of Earth are relatively low,
posing no high challenges for the survival of contemporary life forms. IR derives from natural …
posing no high challenges for the survival of contemporary life forms. IR derives from natural …
Genetics and genomics of radiotherapy toxicity: towards prediction
CM West, GC Barnett - Genome medicine, 2011 - Springer
Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with
the consequences of treatment, and toxicity in a minority limits the radiation doses that can …
the consequences of treatment, and toxicity in a minority limits the radiation doses that can …
The mismatch repair-dependent DNA damage response: Mechanisms and implications
An important role for the DNA mismatch repair (MMR) pathway in maintaining genomic
stability is embodied in its conservation through evolution and the link between loss of MMR …
stability is embodied in its conservation through evolution and the link between loss of MMR …
Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization
Background Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy.
The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is …
The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is …
Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines
HS Gwak, TH Kim, GH Jo, YJ Kim, HJ Kwak, JH Kim… - 2012 - journals.plos.org
Radiation is a core part of therapy for malignant glioma and is often provided following
debulking surgery. However, resistance to radiation occurs in most patients, and the …
debulking surgery. However, resistance to radiation occurs in most patients, and the …