The passage of an individual's genome to future generations is essential for the
maintenance of species and is mediated by highly specialized cells, the germ cells. Genetic …

The Malignant Brain Tumor (MBT) domain is a “chromatin reader”, a protein module that
binds to post-translational modifications on histone tails that are thought to affect a variety of …

The synchronous cleavage divisions of early embryogenesis require coordination of the cell-
cycle oscillator, the dynamics of the cytoskeleton, and the cytoplasm. Yet, it remains unclear …

Distinct histone lysine methylation marks are involved in transcriptional repression linked to
the formation and maintenance of facultative heterochromatin, although the underlying …

Model organisms such as the fruit fly Drosophila melanogaster can help to elucidate the
molecular basis of complex diseases such as cancer. Mutations in the Drosophila gene …

Cell polarity in Drosophila epithelia, oocytes and neuroblasts is controlled by the
evolutionarily conserved PAR/aPKC complex, which consists of the serine-threonine protein …

Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1)
plays an essential role in mammalian cell cycle progression, especially during G2/M, it …

Monomethylation of lysine 20 of histone H4 (H4K20me1) is catalyzed by Set8 and thought to
play important roles in many aspects of genome function that are mediated by H4K20me …

Drosophila oogenesis is an excellent system for the study of developmental cell biology.
Active areas of research include stem cell maintenance, gamete development, pattern …

Lethal 3 malignant brain tumor 1 (L3MBTL1), a homolog of the Drosophila polycomb tumor
suppressor l (3) mbt, contains three tandem MBT repeats (3xMBT) that are critical for …