Clinical applications of many anti-cancer drugs are restricted due to their hydrophobic
nature, requiring use of harmful organic solvents for administration, and poor selectivity and …

Angiogenesis is a process of generation of de-novo blood vessels from already existing
vasculature. It has a crucial role in different physiological process including wound healing …

Tumor vessels can provide oxygen and nutrition for solid tumor tissue, create abnormal
tumor microenvironment (TME), and play a vital role in the development, immune escape …

Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …

Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to
its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging …

Background Limited effective intervention for advanced hepatocellular carcinoma (HCC) is
available. This study aimed to investigate the potential clinical utility of apatinib, a highly …

Lipid nanocapsules (LNCs) are lipid-based nanocarriers that have found application as drug
delivery systems, in diagnostics, and theranostics. They are biocompatible and able to …

The particular characteristics of hypoxia, immune suppression in the tumor
microenvironment, and the lack of accurate imaging guidance lead to the limited effects of …

The transdermal application of actives offers numerous advantages over other conventional
routes. Namely, a stable level of drugs in the bloodstream and reduced side effects are the …

Recent progress in nanomedicine and targeted therapy brings new breeze into the field of
therapeutic applications of tyrosine kinase inhibitors (TKIs). These drugs are known for many …