From asthma and heart disease to diabetes and obesity, the human microbiome plays a role
in the pathogenesis of each chronic health condition plaguing today's society. Recent work …

Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa.
Sleep-inducing inflammatory molecules are activated by increased waking activity and …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Autism spectrum disorders (ASD) are a complex group of neurodevelopmental disorders
encompassing impairments in communication, social interactions and restricted …

Controlled, experimental studies on the effects of acute sleep loss in humans have shown
that mediators of inflammation are altered by sleep loss. Elevations in these mediators have …

Sleep is considered an important modulator of the immune response. Thus, a lack of sleep
can weaken immunity, increasing organism susceptibility to infection. For instance, shorter …

Good sleep is necessary for physical and mental health. For example, sleep loss impairs
immune function, and sleep is altered during infection. Immune signalling molecules are …

1. This paper reviews recent findings on cellular and humoral immunity and inflammatory
markers in depression. 2. 2. It is shown that major depression may be accompanied by …

One mechanism by which blood-borne cytokines might affect the function of the central
nervous system (CNS) is by crossing the blood-brain barrier (BBB) for direct interaction with …

IL-1 is an important mediator of inflammation and tissue damage in multiple organs, both in
experimental animal models of disease and in human diseases. The IL-1 family consists of …