Extracellular vesicles as personalized medicine

DJ Beetler, DN Di Florio, KA Bruno, T Ikezu… - Molecular aspects of …, 2023 - Elsevier
Extracellular vesicles (EVs) are released from all cells in the body, forming an important
intercellular communication network that contributes to health and disease. The contents of …

Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges

S Dutta, S Hornung, HB Taha, G Bitan - Acta neuropathologica, 2023 - Springer
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …

Liquid biopsy in neurological diseases

S Malhotra, MCM Miras, A Pappolla, X Montalban… - Cells, 2023 - mdpi.com
The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …

Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease

C Vandendriessche, D Kapogiannis… - Advanced drug delivery …, 2022 - Elsevier
Extracellular vesicles (EVs) are cell-derived nanoparticles with an important role in
intercellular communication, even across brain barriers. The bidirectional brain-barrier …

Comparative assessment of Alzheimer's disease-related biomarkers in plasma and neuron-derived extracellular vesicles: a nested case-control study

A Manolopoulos, F Delgado-Peraza… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Alzheimer's disease (AD) is currently defined according to biomarkers reflecting
the core underlying neuropathological processes: Aβ deposition, Tau, and …

Huntingtin co-isolates with small extracellular vesicles from blood plasma of TgHD and KI-HD pig models of Huntington's disease and human blood plasma

H Ananbeh, J Novak, S Juhas, J Juhasova… - International journal of …, 2022 - mdpi.com
(1) Background: Huntington's disease (HD) is rare incurable hereditary neurodegenerative
disorder caused by CAG repeat expansion in the gene coding for the protein huntingtin …

[HTML][HTML] Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept

E Eitan, T Thornton-Wells, K Elgart… - Extracellular vesicles …, 2023 - ncbi.nlm.nih.gov
Aims: Blood biomarkers can improve drug development for Alzheimer's disease (AD) and its
treatment. Neuron-derived extracellular vesicles (NDEVs) in plasma offer a minimally …

The role of exosomes as mediators of neuroinflammation in the pathogenesis and treatment of Alzheimer's disease

S Weng, QL Lai, J Wang, L Zhuang, L Cheng… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by
progressive dementia. Accumulation of β–amyloid peptide 1–42 and phosphorylation of tau …

Plasma microglial-derived extracellular vesicles are increased in frail patients with Mild Cognitive Impairment and exert a neurotoxic effect

C Visconte, MT Golia, C Fenoglio, M Serpente… - Geroscience, 2023 - Springer
Extracellular vesicles (EVs) are mediators of cellular communication that can be released by
almost all cell types in both physiological and pathological conditions and are present in …

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

M Chatterjee, S Özdemir, C Fritz, W Möbius… - Nature Medicine, 2024 - nature.com
Minimally invasive biomarkers are urgently needed to detect molecular pathology in
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that …