Extracellular vesicles as personalized medicine
Extracellular vesicles (EVs) are released from all cells in the body, forming an important
intercellular communication network that contributes to health and disease. The contents of …
intercellular communication network that contributes to health and disease. The contents of …
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …
Liquid biopsy in neurological diseases
S Malhotra, MCM Miras, A Pappolla, X Montalban… - Cells, 2023 - mdpi.com
The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease
C Vandendriessche, D Kapogiannis… - Advanced drug delivery …, 2022 - Elsevier
Extracellular vesicles (EVs) are cell-derived nanoparticles with an important role in
intercellular communication, even across brain barriers. The bidirectional brain-barrier …
intercellular communication, even across brain barriers. The bidirectional brain-barrier …
Comparative assessment of Alzheimer's disease-related biomarkers in plasma and neuron-derived extracellular vesicles: a nested case-control study
A Manolopoulos, F Delgado-Peraza… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Alzheimer's disease (AD) is currently defined according to biomarkers reflecting
the core underlying neuropathological processes: Aβ deposition, Tau, and …
the core underlying neuropathological processes: Aβ deposition, Tau, and …
Huntingtin co-isolates with small extracellular vesicles from blood plasma of TgHD and KI-HD pig models of Huntington's disease and human blood plasma
H Ananbeh, J Novak, S Juhas, J Juhasova… - International journal of …, 2022 - mdpi.com
(1) Background: Huntington's disease (HD) is rare incurable hereditary neurodegenerative
disorder caused by CAG repeat expansion in the gene coding for the protein huntingtin …
disorder caused by CAG repeat expansion in the gene coding for the protein huntingtin …
[HTML][HTML] Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept
E Eitan, T Thornton-Wells, K Elgart… - Extracellular vesicles …, 2023 - ncbi.nlm.nih.gov
Aims: Blood biomarkers can improve drug development for Alzheimer's disease (AD) and its
treatment. Neuron-derived extracellular vesicles (NDEVs) in plasma offer a minimally …
treatment. Neuron-derived extracellular vesicles (NDEVs) in plasma offer a minimally …
The role of exosomes as mediators of neuroinflammation in the pathogenesis and treatment of Alzheimer's disease
S Weng, QL Lai, J Wang, L Zhuang, L Cheng… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by
progressive dementia. Accumulation of β–amyloid peptide 1–42 and phosphorylation of tau …
progressive dementia. Accumulation of β–amyloid peptide 1–42 and phosphorylation of tau …
Plasma microglial-derived extracellular vesicles are increased in frail patients with Mild Cognitive Impairment and exert a neurotoxic effect
C Visconte, MT Golia, C Fenoglio, M Serpente… - Geroscience, 2023 - Springer
Extracellular vesicles (EVs) are mediators of cellular communication that can be released by
almost all cell types in both physiological and pathological conditions and are present in …
almost all cell types in both physiological and pathological conditions and are present in …
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
M Chatterjee, S Özdemir, C Fritz, W Möbius… - Nature Medicine, 2024 - nature.com
Minimally invasive biomarkers are urgently needed to detect molecular pathology in
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that …
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that …