Chronic headache is particularly prevalent in migraineurs and it can progress to a condition
known as medication overuse headache (MOH). MOH is a secondary headache caused by …

Until now, a satisfying account of the cause and purpose of migraine has remained elusive.
We explain migraine within the frameworks of allostasis (the situationally-flexible, forward …

Background Migraine is a complex, multifaceted, and disabling headache disease that is
often complicated by gastrointestinal (GI) conditions, such as gastroparesis, functional …

In recent years, numerous efforts have been made to identify reliable biomarkers useful in
migraine diagnosis and progression or associated with the response to a specific treatment …

Although pain is a widely known phenomenon and an important clinical symptom that
occurs in numerous diseases, its mechanisms are still barely understood. Owing to the …

Abstract Objective Refractory migraine (Ref‐M) represents a conundrum that headache
experts have to face with. We aim to investigate whether a peculiar profile may characterize …

Background: Dietary iron intake and serum ferritin in relation to severe headache or
migraine remain largely unknown. Therefore, we investigated the associations between …

How do monoamines influence the perceptual and behavioral aspects of brain function? A
library of information regarding the genetic, molecular, cellular, and function of monoamines …

Migraine is a recurrent disease with complex pathogenesis and is difficult to cure. At present,
commercially available western migraine drugs are prone to generate side effects while …

Background The pathogenesis of chronic migraine remains unresolved. Recent studies
have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine …