Beyond the limiting gap length: peripheral nerve regeneration through implantable nerve guidance conduits

ER Riva, M Özkan, E Contreras, S Pawar… - Biomaterials …, 2024 - pubs.rsc.org
Peripheral nerve damage results in the loss of sensorimotor and autonomic functions, which
is a significant burden to patients. Furthermore, nerve injuries greater than the limiting gap …

The bumpy road to stem cell therapies: Rational design of surface topographies to dictate stem cell mechanotransduction and fate

J Carthew, JBJ Taylor, MR Garcia-Cruz… - … Applied Materials & …, 2022 - ACS Publications
Cells sense and respond to a variety of physical cues from their surrounding
microenvironment, and these are interpreted through mechanotransductive processes to …

Aligned electrospun poly(l-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways

J Xie, X Wu, S Zheng, K Lin, J Su - Journal of nanobiotechnology, 2022 - Springer
Delayed wound healing remains a challenge, and macrophages play an important role in
the inflammatory process of wound healing. Morphological changes in macrophages can …

Development of porous scaffolds based on the in situ synthesis of biphasic calcium phosphate in a gelatin-polyvinyl alcohol matrix for bone tissue engineering

A Hassouna, H Elgharbawy, R Morsy - Journal of Molecular Structure, 2023 - Elsevier
Abstract 3D porous scaffolds are the preferred scaffold for tissue engineering applications
that require good biocompatibility and mechanical properties. However, those scaffolds …

3D printed poly (lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

ME Grigora, Z Terzopoulou, D Baciu, T Steriotis… - Journal of Materials …, 2023 - Springer
In this work, the effect of two different types of bioactive coatings on the properties of 3D
printed poly (lactic acid)/montmorillonite (PLA/MMT) nanocomposite scaffolds was …

Exploring the physicochemical, electroactive, and biodelivery properties of metal nanoparticles on peripheral nerve regeneration

M Sharifi, MK Farahani, M Salehi, A Atashi… - ACS Biomaterials …, 2022 - ACS Publications
Despite the advances in the regeneration/rehabilitation field of damaged tissues, the
functional recovery of peripheral nerves (PNs), especially in a long gap injury, is considered …

Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting

J Adhikari, A Roy, A Chanda, DA Gouripriya… - Biomaterials …, 2023 - pubs.rsc.org
The extracellular matrix (ECM) of the tissue organ exhibits a topography from the nano to
micrometer range, and the design of scaffolds has been inspired by the host environment …

Development of a polyacrylamide/chitosan composite hydrogel conduit containing synergistic cues of elasticity and topographies for promoting peripheral nerve …

F Liu, J Xu, A Liu, L Wu, D Wang, Q Han, T Zheng… - Biomaterials …, 2022 - pubs.rsc.org
Substrate elasticity and topographical guidance are crucial factors for regulating tissue
regeneration, but the synergistic effects of both cues on peripheral nerve regeneration are …

3D chitosan scaffolds support expansion of human neural stem cells in chemically defined condition

FC Chang, MM James, AM Qassab, Y Zhou, Y Ando… - Matter, 2023 - cell.com
The use of human neural stem cells (hNSCs) for clinical cell therapies is limited by the lack
of effective culture substrates to produce hNSCs. Animal-sourced substrates could result in …

Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics

M Sharifi, M Kamalabadi-Farahani, M Salehi… - Journal of …, 2024 - Springer
Several studies suggest that topographical patterns influence nerve cell fate. Efforts have
been made to improve nerve cell functionality through this approach, focusing on …