Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts …

In 1971, Gabbiani and co-workers discovered and characterized the “modification of
fibroblasts into cells which are capable of an active spasm”(contraction) in rat wound …

Activated fibroblasts promote physiological wound repair following tissue injury. However,
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …

Pathological remodeling of the extracellular matrix (ECM) by activated myofibroblasts is a
hallmark of fibrotic diseases and desmoplastic tumors. Activation of myofibroblasts occurs in …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease with high mortality that
commonly occurs in middle-aged and older adults. IPF, characterized by a decline in lung …

Abstract Purpose: The aberrantly upregulated Friend leukemia virus integration 1 (FLI1) is
closely correlated with the malignant phenotype of small cell lung cancer (SCLC). It is …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Pulmonary fibrosis is characterised by excessive scarring in the lung which leads to
compromised lung function, serious breathing problems and in some diseases, death. It …