The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the
neuropil and interact with synapses. The mechanisms that control the establishment of …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Identifying genes involved in biological processes is critical for understanding the molecular
building blocks of life. We used engineered CRISPR (clustered regularly interspaced short …

The brain processes information by transmitting signals at synapses, which connect neurons
into vast networks of communicating cells. In these networks, synapses not only transmit …

Proper establishment of synapses is critical for constructing functional circuits. Interactions
between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of …

Neural communication networks form the fundamental basis for brain function. These
communication networks are enabled by emitted ligands such as neurotransmitters, which …

Schizophrenia is a highly debilitating mental disorder that affects∼ 1% of the general
population, yet it continues to be poorly understood. Recent studies have identified …

The primate neocortex exerts high cognitive ability and strong information processing
capacity. Here, we establish a single-cell RNA sequencing dataset of 133,454 macaque …