Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Pulmonary arterial hypertension (PAH) is a progressive and fatal lung disease of
multifactorial etiology. Most of the available drugs and FDA-approved therapies for treating …

Background: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial
hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 …

Pulmonary hypertension (PH) is a progressive cardiovascular disorder in which local
vascular inflammation leads to increased pulmonary vascular remodeling and ultimately to …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Background Pulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH),
is a type of pulmonary vascular disease characterized by abnormal contraction and …

Over the past decades, a better understanding of the genetic and molecular alterations
underlying several respiratory diseases has encouraged the development of new …

During spaceflight, astronauts are exposed to multiple unique environmental factors,
particularly microgravity and ionizing radiation, that can cause a range of harmful health …

Pulmonary arterial hypertension (PAH) is a sex-biased disease with a poorly understood
female prevalence. Emerging research suggests that nonhormonal factors, such as the XX …

Pulmonary arterial hypertension (PAH) is a rare and chronic lung disease characterized by
progressive occlusion of the small pulmonary arteries, which is associated with structural …