Background The worldwide corona virus disease outbreak, generally known as COVID-19
pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission …

Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …

This article reports on an American Society of Pharmacology and Therapeutics, Division of
Drug Metabolism and Disposition symposium held at Experimental Biology on April 2, 2022 …

Background Age-related changes in immune cell composition and functionality are
associated with multimorbidity and mortality. However, many centenarians delay the onset of …

Although people with HIV are living longer, as they age they remain disproportionately
burdened with multimorbidity that is exacerbated in resource-poor settings. The geroscience …

Bronchopulmonary dysplasia (BPD) is the most common lung disease of extreme
prematurity, yet mechanisms that associate with or identify neonates with increased …

Host-directed therapeutics targeting immune dysregulation are considered the most
promising approach to address the unmet clinical need for acute lung injury (ALI)/acute …

Ibrutinib has potential therapeutic or protective effects against viral-and bacterial-induced
acute lung injury (ALI), likely by modulating the Bruton tyrosine kinase (BTK) signaling …

Background Identifying factors that determine the frequency of latently infected CD4+ T cells
on antiretroviral therapy (ART) may inform strategies for human immunodeficiency virus …

Among carbapenem-resistant Enterobacterales (CRE) are diverse mechanisms, including
those that are resistant to meropenem but susceptible to ertapenem, adding further …