Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among
inputs, but how these factors interact during realistic patterns of activity is unknown. Here we …

NEURON is a simulation environment for models of individual neurons and networks of
neurons that are closely linked to experimental data. NEURON provides tools for …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

The hippocampal theta rhythm plays important roles in information processing; however, the
mechanisms of its generation are not well understood. We developed a data-driven …

Action potential propagation links information processing in different regions of the dendritic
tree. To examine the contribution of dendritic morphology to the efficacy of propagation …

Background There is evidence that transcranial direct current stimulation (tDCS) can
improve learning performance. Arguably, this effect is related to long term potentiation (LTP) …

The dendrites of pyramidal neurons have markedly different electrical properties from those
of the soma, owing to the non-uniform distribution of voltage-gated ion channels in …

We describe a mechanism for coincidence detection mediated by the interaction between
backpropagating action potentials and EPSPs in neocortical pyramidal neurons. At distal …