Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …

Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …

Further advances in cell engineering are needed to increase the efficacy of chimeric antigen
receptor (CAR) and other T cell-based therapies,,,–. As T cell differentiation and functional …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

Epigenetic Therapies for Cancer | New England Journal of Medicine Skip to main content The
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Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Cancer immunotherapy based on genetically redirecting T cells has been used successfully
to treat B cell malignancies,–. In this strategy, the T cell genome is modified by integration of …

Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
eukaryotic messenger RNAs (mRNAs), plays critical roles in many bioprocesses. However …