CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Stem-like glioma cells reside within a perivascular niche and display hallmark radiation
resistance. An understanding of the mechanisms underlying these properties will be vital for …

Abstract The PD-L1 (CD274) immune-checkpoint ligand is often upregulated in cancers to
inhibit T cells and elicit immunosuppression. Independent of this activity, PD-L1 has recently …

The stem cell niche provides a regulatory microenvironment for cells as diverse as totipotent
embryonic stem cells to cancer stem cells (CSCs) which exhibit stem cell-like characteristics …

CD44 is a hyaluronan binding cell surface signal transducing receptor that influences
motility, cell survival and proliferation as well as the formation of tumor microenvironment …

Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation, but also dormancy and cellular …

Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

CD44 was recently identified as a cancer initiation marker on the cell membrane. The
cytoplasmic tail of CD44 is known to bind ERM (ezrin, radixin, moesin) proteins, cytoskeletal …