Bone and brain metastases are a very common secondary localization of disease in patients
with lung cancer. The prognosis of these patients is still poor with a median survival of less …

Bone-targeted treatments with bisphosphonates and denosumab, which reduce bone
resorption, are known to reduce the risk of skeletal complications and prevent treatment …

Cervical cancer is one of the gravest threats to women's lives. It is estimated that over a
million women worldwide currently have cervical cancer. Most of these women have not …

Abstract the present retrospective study was performed to evaluate the clinicopathological
characteristics associated with distant metastasis from non‑small‑cell lung cancer (NSCLC) …

Summary Background Analysis of the Austrian Breast and Colorectal Cancer Study Group
trial-12 (ABCSG-12) at 48 months' follow-up showed that addition of zoledronic acid to …

Background Based on preclinical data for the antitumour effect of zoledronate in
osteosarcoma, we assessed whether zoledronate combined with chemotherapy and surgery …

BACKGROUND: Postmenopausal breast cancer (BC) patients receiving adjuvant aromatase
inhibitor therapy are at risk of progressive bone loss and fractures. Zoledronic acid inhibits …

The bone marrow microenvironment provides a site for cancer cells to evade systemic
anticancer therapy. Dormant tumor micrometastases are believed to be the source of …

Background Data are limited regarding bone metastases from colorectal cancer (CRC). The
objective of this study was to survey the natural history of bone metastasis in CRC. Patients …

Metastatic bone cancer occurs in every type of cancer but is prevalent in lung, breast, and
prostate cancers. These metastases can cause extensive morbidity, including a range of …