Causes and consequences of RNA polymerase II stalling during transcript elongation
M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
Reciprocal links between pre-messenger RNA 3′-end processing and genome stability
M Dutertre, R Sfaxi, S Vagner - Trends in Biochemical Sciences, 2021 - cell.com
The 3′-end processing of most pre-messenger RNAs (pre-mRNAs) involves RNA cleavage
and polyadenylation and is coupled to transcription termination. In both yeast and human …
and polyadenylation and is coupled to transcription termination. In both yeast and human …
Hydroxyurea and inactivation of checkpoint kinase MEC1 inhibit transcription termination and pre-mRNA cleavage at polyadenylation sites in budding yeast
The DNA damage response (DDR) is an evolutionarily conserved process essential for cell
survival. The transcription changes triggered by DDR depend on the nature of DNA damage …
survival. The transcription changes triggered by DDR depend on the nature of DNA damage …
Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis
A Chakraborty, N Tapryal, T Venkova… - Proceedings of the …, 2020 - National Acad Sciences
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease
caused by CAG (encoding glutamine) repeat expansion in the Ataxin-3 (ATXN3) gene. We …
caused by CAG (encoding glutamine) repeat expansion in the Ataxin-3 (ATXN3) gene. We …
[HTML][HTML] Mechanisms of RNA Polymerase II termination at the 3'-end of genes
DL Martinez, JQ Svejstrup - Journal of Molecular Biology, 2024 - Elsevier
Abstract RNA polymerase II (RNAPII) is responsible for the synthesis of a diverse set of RNA
molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding …
molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding …
Mutations in yeast Pcf11, a conserved protein essential for mRNA 3′ end processing and transcription termination, elicit the Environmental Stress Response
The Pcf11 protein is an essential subunit of the large complex that cleaves and
polyadenylates eukaryotic mRNA precursor. It has also been functionally linked to gene …
polyadenylates eukaryotic mRNA precursor. It has also been functionally linked to gene …
A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins
M Zhang, JM Berk, AB Mehrtash, J Kanyo… - PLoS …, 2022 - journals.plos.org
Protein ubiquitylation is an important posttranslational modification affecting a wide range of
cellular processes. Due to the low abundance of ubiquitylated species in biological samples …
cellular processes. Due to the low abundance of ubiquitylated species in biological samples …
DEF1: much more than an RNA polymerase degradation factor
OT Akinniyi, JC Reese - DNA repair, 2021 - Elsevier
Degradation Factor 1 was discovered 20 years ago as a yeast protein copurifying with
Rad26, a helicase involved in transcription-coupled DNA repair. It was subsequently shown …
Rad26, a helicase involved in transcription-coupled DNA repair. It was subsequently shown …
Ipa1 is an RNA polymerase II elongation factor that facilitates termination by maintaining levels of the poly (A) site endonuclease Ysh1
EL Pearson, JH Graber, SD Lee, KS Naggert… - Cell reports, 2019 - cell.com
The yeast protein Ipa1 was recently discovered to interact with the Ysh1 endonuclease of
the pre-mRNA cleavage and polyadenylation (C/P) machinery, and Ipa1 mutation impairs …
the pre-mRNA cleavage and polyadenylation (C/P) machinery, and Ipa1 mutation impairs …
A SUMO-dependent pathway controls elongating RNA Polymerase II upon UV-induced damage
I Heckmann, MJ Kern, B Pfander, S Jentsch - Scientific Reports, 2019 - nature.com
Abstract RNA polymerase II (RNAPII) is the workhorse of eukaryotic transcription and
produces messenger RNAs and small nuclear RNAs. Stalling of RNAPII caused by …
produces messenger RNAs and small nuclear RNAs. Stalling of RNAPII caused by …