Seizure prediction—ready for a new era
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …
majority of people with epilepsy regard the unpredictability of seizures as a major issue …
Cognition and dementia in older patients with epilepsy
With advances in healthcare and an ageing population, the number of older adults with
epilepsy is set to rise substantially across the world. In developed countries the highest …
epilepsy is set to rise substantially across the world. In developed countries the highest …
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy
AN Khambhati, A Shafi, VR Rao… - Science Translational …, 2021 - science.org
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …
Modulation of brain hyperexcitability: potential new therapeutic approaches in Alzheimer's disease
People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …
Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer's disease
Since the first demonstrations of network hyperexcitability in scientific models of Alzheimer's
disease, a growing body of clinical studies have identified subclinical epileptiform activity …
disease, a growing body of clinical studies have identified subclinical epileptiform activity …
Facilitating early parent-infant emotional connection improves cortical networks in preterm infants
P Yrjölä, MM Myers, MG Welch, NJ Stevenson… - Science translational …, 2022 - science.org
Exposure to environmental adversities during early brain development, such as preterm
birth, can affect early brain organization. Here, we studied whether development of cortical …
birth, can affect early brain organization. Here, we studied whether development of cortical …
Interictal epileptiform discharges shape large-scale intercortical communication
Dynamic interactions between remote but functionally specialized brain regions enable
complex information processing. This intercortical communication is disrupted in the neural …
complex information processing. This intercortical communication is disrupted in the neural …
[HTML][HTML] An updated systematic review and meta-analysis of brain network organization in focal epilepsy: Looking back and forth
G Slinger, WM Otte, KPJ Braun… - … & Biobehavioral Reviews, 2022 - Elsevier
Abnormalities of the brain network organization in focal epilepsy have been extensively
quantified. However, the extent and directionality of abnormalities are highly variable and …
quantified. However, the extent and directionality of abnormalities are highly variable and …
Impaired vigilance networks in temporal lobe epilepsy: mechanisms and clinical implications
Mesial temporal lobe epilepsy (mTLE) is a neurological disorder in which patients suffer
from frequent consciousness‐impairing seizures, broad neurocognitive deficits, and …
from frequent consciousness‐impairing seizures, broad neurocognitive deficits, and …
Measuring the effects of first antiepileptic medication in Temporal Lobe Epilepsy: Predictive value of quantitative-EEG analysis
L Ricci, G Assenza, P Pulitano, V Simonelli… - Clinical …, 2021 - Elsevier
Objective To determine the quantitative EEG responses in a population of drug-naïve
patients with Temporal Lobe Epilepsy (TLE) after Levetiracetam (LEV) initiation as first …
patients with Temporal Lobe Epilepsy (TLE) after Levetiracetam (LEV) initiation as first …