Seizure prediction—ready for a new era

L Kuhlmann, K Lehnertz, MP Richardson… - Nature Reviews …, 2018 - nature.com
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

Cognition and dementia in older patients with epilepsy

A Sen, V Capelli, M Husain - Brain, 2018 - academic.oup.com
With advances in healthcare and an ageing population, the number of older adults with
epilepsy is set to rise substantially across the world. In developed countries the highest …

Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy

AN Khambhati, A Shafi, VR Rao… - Science Translational …, 2021 - science.org
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …

Modulation of brain hyperexcitability: potential new therapeutic approaches in Alzheimer's disease

S Toniolo, A Sen, M Husain - International journal of molecular sciences, 2020 - mdpi.com
People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early-onset Alzheimer's disease

KG Ranasinghe, K Kudo, L Hinkley, A Beagle, H Lerner… - Brain, 2022 - academic.oup.com
Since the first demonstrations of network hyperexcitability in scientific models of Alzheimer's
disease, a growing body of clinical studies have identified subclinical epileptiform activity …

Facilitating early parent-infant emotional connection improves cortical networks in preterm infants

P Yrjölä, MM Myers, MG Welch, NJ Stevenson… - Science translational …, 2022 - science.org
Exposure to environmental adversities during early brain development, such as preterm
birth, can affect early brain organization. Here, we studied whether development of cortical …

Interictal epileptiform discharges shape large-scale intercortical communication

P Dahal, N Ghani, A Flinker, P Dugan, D Friedman… - Brain, 2019 - academic.oup.com
Dynamic interactions between remote but functionally specialized brain regions enable
complex information processing. This intercortical communication is disrupted in the neural …

[HTML][HTML] An updated systematic review and meta-analysis of brain network organization in focal epilepsy: Looking back and forth

G Slinger, WM Otte, KPJ Braun… - … & Biobehavioral Reviews, 2022 - Elsevier
Abnormalities of the brain network organization in focal epilepsy have been extensively
quantified. However, the extent and directionality of abnormalities are highly variable and …

Impaired vigilance networks in temporal lobe epilepsy: mechanisms and clinical implications

DJ Englot, VL Morgan, C Chang - Epilepsia, 2020 - Wiley Online Library
Mesial temporal lobe epilepsy (mTLE) is a neurological disorder in which patients suffer
from frequent consciousness‐impairing seizures, broad neurocognitive deficits, and …

Measuring the effects of first antiepileptic medication in Temporal Lobe Epilepsy: Predictive value of quantitative-EEG analysis

L Ricci, G Assenza, P Pulitano, V Simonelli… - Clinical …, 2021 - Elsevier
Objective To determine the quantitative EEG responses in a population of drug-naïve
patients with Temporal Lobe Epilepsy (TLE) after Levetiracetam (LEV) initiation as first …