Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …

Infections with human cytomegalovirus (HCMV) are a major cause of morbidity and mortality
in humans with acquired or developmental deficits in innate and adaptive immunity. In the …

Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Intravenous ganciclovir is the standard treatment for cytomegalovirus disease in solid organ
transplant recipients. Oral valganciclovir is a more convenient alternative. In a randomized …

Though an important cause of morbidity and mortality in solid organ transplantation (SOT),
the long-term outcomes of cytomegalovirus (CMV) disease treatment have not been well …

Cytomegalovirus (CMV) is a common viral pathogen in the transplant population and is
associated with significant morbidity and mortality. CMV prevention is paramount; however …

Type I interferons, a protein family of multiple IFNαs and a single IFNβ, initially identified on
the basis of their antiviral activities have recently been attributed important roles in bacterial …

Natural killer (NK) cells are important in the host resistance to viral infections. They are
among the first cells to sense the release of proinflammatory cytokines, as well as the …

Natural killer cells were named after their ability to mediate spontaneous cytotoxicity during
innate immune responses. However, it has become clear in recent years that they play an …