The cell biology of mitochondrial membrane dynamics
M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …
mitochondria are often considered the 'powerhouses of the cell'. However, our …
The role of mitochondrial fission in cardiovascular health and disease
JM Quiles, ÅB Gustafsson - Nature Reviews Cardiology, 2022 - nature.com
Mitochondria are organelles involved in the regulation of various important cellular
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …
processes, ranging from ATP generation to immune activation. A healthy mitochondrial …
Mitochondrial quality control mechanisms as molecular targets in diabetic heart
X Chang, Y Li, C Cai, F Wu, J He, Y Zhang, J Zhong… - Metabolism, 2022 - Elsevier
Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …
addition to their canonical metabolic actions, mitochondria influence various other aspects of …
[HTML][HTML] Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway
C Cai, Z Guo, X Chang, Z Li, F Wu, J He, T Cao… - Redox biology, 2022 - Elsevier
Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …
[HTML][HTML] Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control
X Chang, A Lochner, HH Wang, S Wang, H Zhu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …
structural integrity and microcirculation function for coronary microvasculature. Impaired …
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment
With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to
explore non-conventional therapeutic measures to alleviate the burden of CVD on global …
explore non-conventional therapeutic measures to alleviate the burden of CVD on global …
[HTML][HTML] Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury
Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …
[HTML][HTML] Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis
R Zou, W Shi, J Qiu, N Zhou, N Du, H Zhou… - Cardiovascular …, 2022 - Springer
Background Empagliflozin has been reported to protect endothelial cell function, regardless
of diabetes status. However, the role of empagliflozin in microvascular protection during …
of diabetes status. However, the role of empagliflozin in microvascular protection during …
[HTML][HTML] SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the …
L Ma, R Zou, W Shi, N Zhou, S Chen, H Zhou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Given the importance of microvascular injury in infarct formation and
expansion, development of therapeutic strategies for microvascular protection against …
expansion, development of therapeutic strategies for microvascular protection against …
New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …