Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Homorepeats (or polyX), protein segments containing repetitions of the same amino acid,
are abundant in proteomes from all kingdoms of life and are involved in crucial biological …

A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …

In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted
translation are modified with C-terminal polyalanine tails (" Ala-tails") that function outside …

From yeast to humans, polyglutamine (polyQ) repeat tracts are found frequently in the
proteome and are particularly prominent in the activation domains of transcription factors …

Nuclear magnetic resonance (NMR) studies of large biomolecular machines and highly
repetitive proteins remain challenging due to the difficulty of assigning frequencies to …

Currently, nine polyglutamine (polyQ) expansion diseases are known. They include
spinocerebellar ataxias (SCA1, 2, 3, 6, 7, 17), spinal and bulbar muscular atrophy (SBMA) …

Motivation Poly-alanine (polyA) regions are protein stretches mostly composed of alanines.
Despite their abundance in eukaryotic proteomes and their association to nine inherited …

The binding of intrinsically disordered proteins to globular ones can require the folding of
motifs into α-helices. These interactions offer opportunities for therapeutic intervention but …

Nine polyglutamine (polyQ) proteins have already been identified that are considered to be
associated with the pathologies of neurodegenerative disorders called polyQ diseases, but …