Translational control in cancer etiology
D Ruggero - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …
primary focus in cancer research. It has now been established that genetic alterations in …
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors
Abstract Phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3 or PIP3) mediates
signalling pathways as a second messenger in response to extracellular signals. Although …
signalling pathways as a second messenger in response to extracellular signals. Although …
Identifying proteins that bind to specific RNAs-focus on simple repeat expansion diseases
M Jazurek, A Ciesiolka, J Starega-Roslan… - Nucleic acids …, 2016 - academic.oup.com
RNA–protein complexes play a central role in the regulation of fundamental cellular
processes, such as mRNA splicing, localization, translation and degradation. The …
processes, such as mRNA splicing, localization, translation and degradation. The …
Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells
B Fafilek, M Krausova, M Vojtechova, V Pospichalova… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: The Wnt signaling pathway is required for maintenance of the
intestinal epithelia; blocking this pathway reduces the proliferative capacity of the intestinal …
intestinal epithelia; blocking this pathway reduces the proliferative capacity of the intestinal …
Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance
JY Shin, I Méndez-López, Y Wang, AP Hays, K Tanji… - Developmental cell, 2013 - cell.com
X-linked Emery-Dreifuss muscular dystrophy is caused by loss of function of emerin, an
integral protein of the inner nuclear membrane. Yet emerin null mice are essentially normal …
integral protein of the inner nuclear membrane. Yet emerin null mice are essentially normal …
The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells
M Huranová, I Ivani, A Benda, I Poser, Y Brody… - Journal of Cell …, 2010 - rupress.org
Precursor messenger RNA (pre-mRNA) splicing is catalyzed by the spliceosome, a large
ribonucleoprotein (RNP) complex composed of five small nuclear RNP particles (snRNPs) …
ribonucleoprotein (RNP) complex composed of five small nuclear RNP particles (snRNPs) …
Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives
A Li, A Bouhss, MJ Clément, C Bauvais… - Frontiers in Molecular …, 2023 - frontiersin.org
In recent years, RNA has gained traction both as a therapeutic molecule and as a
therapeutic target in several human pathologies. In this review, we consider the approach of …
therapeutic target in several human pathologies. In this review, we consider the approach of …
Adaptation of RiPCA for the live-cell detection of mRNA-protein interactions
DM Soueid, AL Garner - Biochemistry, 2023 - ACS Publications
RNA-binding proteins (RBPs) act as essential regulators of cell fate decisions, through their
ability to bind and regulate the activity of cellular RNAs. For protein-coding mRNAs, RBPs …
ability to bind and regulate the activity of cellular RNAs. For protein-coding mRNAs, RBPs …
Screening approaches for targeting ribonucleoprotein complexes: a new dimension for drug discovery
VG D'Agostino, D Sighel, C Zucal… - … Life Sciences R&D, 2019 - journals.sagepub.com
RNA-binding proteins (RBPs) are pleiotropic factors that control the processing and
functional compartmentalization of transcripts by binding primarily to mRNA untranslated …
functional compartmentalization of transcripts by binding primarily to mRNA untranslated …
Quantifying RNA–protein interactions in situ using modified-MTRIPs and proximity ligation
J Jung, AW Lifland, C Zurla, EJ Alonas… - Nucleic acids …, 2013 - academic.oup.com
The stabilization, translation and degradation of RNA are regulated by interactions between
trans-acting factors, such as microRNA and RNA-binding proteins (RBP). In order to …
trans-acting factors, such as microRNA and RNA-binding proteins (RBP). In order to …