[HTML][HTML] The SLC9A-C mammalian Na+/H+ exchanger family: molecules, mechanisms, and physiology

SF Pedersen, L Counillon - Physiological reviews, 2019 - journals.physiology.org
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

[HTML][HTML] Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism

L Counillon, Y Bouret, I Marchiq… - Biochimica et Biophysica …, 2016 - Elsevier
Abstract The Na+/H+-exchanger NHE1 and the monocarboxylate transporters MCT1 and
MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1 …

Na+/H+ Exchangers

J Orlowski, S Grinstein - Comprehensive Physiology, 2011 - Wiley Online Library
Tightly coupled exchange of Na+ for H+ occurs across the surface membrane of virtually all
living cells. For years, the underlying molecular entity was unknown and the full …

Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers

R Hendus-Altenburger, BB Kragelund… - Current topics in …, 2014 - Elsevier
Mammalian Na+/H+ exchangers of the SLC9A family are widely expressed and involved in
numerous essential physiological processes. Their primary function is to mediate the 1: 1 …

Structural and functional insights into the cardiac Na+/H+ exchanger

BL Lee, BD Sykes, L Fliegel - Journal of Molecular and Cellular Cardiology, 2013 - Elsevier
The NHE1 isoform of the Na+/H+ exchanger is present in the plasma membrane of the
mammalian myocardium where it functions to regulate intracellular pH by exchanging one …

[HTML][HTML] Topological analysis of the Na+/H+ exchanger

Y Liu, A Basu, X Li, L Fliegel - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed integral
membrane protein present in mammalian cells. It is made up of a hydrophobic 500 amino …

Structural and functional analysis of transmembrane segment VI of the NHE1 isoform of the Na+/H+ exchanger

J Tzeng, BL Lee, BD Sykes, L Fliegel - Journal of Biological Chemistry, 2010 - ASBMB
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein. It
resides on the plasma membrane of cells and regulates intracellular pH in mammals by …

[HTML][HTML] Diverse residues of intracellular loop 5 of the Na+/H+ exchanger modulate proton sensing, expression, activity and targeting

KY Wong, R McKay, Y Liu, K Towle, Y Elloumi… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that
regulates intracellular pH (pH i) by removing a single intracellular proton in exchange for …

Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2

A Ullah, G Kemp, B Lee, C Alves, H Young… - Journal of Biological …, 2013 - ASBMB
Sod2 is the plasma membrane Na+/H+ exchanger of the fission yeast Schizosaccharomyces
pombe. It provides salt tolerance by removing excess intracellular sodium (or lithium) in …

Acidic residues of extracellular loop 3 of the Na+/H+ exchanger type 1 are important in cation transport

X Li, S Quan, T Corsiatto, L Fliegel - Molecular and Cellular Biochemistry, 2020 - Springer
Mammalian Na+/H+ exchanger type I isoform (NHE1) is a ubiquitously expressed
membrane protein that regulates intracellular pH (pHi) by removing one intracellular proton …