Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

Fibrosis and remodeling of the right ventricle (RV) are associated with RV dysfunction and
mortality of patients with pulmonary hypertension (PH) but it is unknown how much RV …

Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …

The development of tyrosine kinase inhibitors (TKI) represents a major milestone in
oncology. However, their use has been found to be associated with serious toxicities that …

Pulmonary arterial hypertension (PAH) has been frequently compared with a type of
malignant disease and has an incredible number of pathogenic mechanisms similar to …

Rationale: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia
via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation …

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac
fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory …

Adaptation of right ventricular (RV) function to increased afterload—known as RV–arterial
coupling—is a key determinant of prognosis in pulmonary hypertension. However …

Obesity is a pre-disposing condition for chronic obstructive pulmonary disease, asthma, and
pulmonary arterial hypertension. Accumulating evidence suggests that metabolic influences …

Current therapy of pulmonary arterial hypertension (PAH) is inadequate.
Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in …