Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms,
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS).
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …

After 20 years since its conception, click chemistry has come of age and we believe the time
has come to evaluate if the copper-catalyzed azide alkyne cycloaddition (CuCAAC) reaction …

The N-acylsulfonamide functional group is a feature of the pharmacophore of several
biologically active molecules, including marketed drugs. Although this acidic moiety …

Emergence of drug resistance and adverse effects often affect the efficacy of nucleoside
analogues in the therapy of Herpes simplex type 1 (HSV-1) and type 2 (HSV-2) infections …

The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase
(h DHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from …

AKR1C3 is an enzyme that is overexpressed in several types of radiotherapy-and
chemotherapy-resistant cancers. Despite AKR1C3 is a validated target for drug …

The aldo-keto reductase 1C3 (AKR1C3) enzyme is considered an attractive target in
Castration Resistant Prostate Cancer (CRPC) because of its role in the biosynthesis of …

Herein we report the synthesis of a series of amino acid-derived triazoles by an
organocatalytic cycloaddition reaction between azides and carbonyl compounds, catalyzed …