Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression

JN Constantino, T Charman - The lancet neurology, 2016 - thelancet.com
Recent discoveries about the pathogenesis and symptom structure of autism spectrum
disorders (ASDs) are challenging traditional nosology and driving efforts to reconceptualise …

Toward a conceptual framework for early brain and behavior development in autism

J Piven, JT Elison, MJ Zylka - Molecular psychiatry, 2017 - nature.com
Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have
demonstrated that the defining features of autism are not present in the first year of life but …

[HTML][HTML] Early brain development in infants at high risk for autism spectrum disorder

HC Hazlett, H Gu, BC Munsell, SH Kim, M Styner… - Nature, 2017 - nature.com
Brain enlargement has been observed in children with autism spectrum disorder (ASD), but
the timing of this phenomenon, and the relationship between ASD and the appearance of …

Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder

S Zuffa, P Schimmel, A Gonzalez-Santana… - Translational …, 2023 - nature.com
Evidence from cross-sectional human studies, and preliminary microbial-based intervention
studies, have implicated the microbiota-gut-brain axis in the neurobiology of autism …

Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study

S Ozonoff, GS Young, RJ Landa, J Brian… - Journal of Child …, 2015 - Wiley Online Library
Background The diagnosis of autism spectrum disorder (ASD) made before age 3 has been
found to be remarkably stable in clinic‐and community‐ascertained samples. The stability of …

Autism treatment in the first year of life: a pilot study of infant start, a parent-implemented intervention for symptomatic infants

SJ Rogers, L Vismara, AL Wagner… - Journal of autism and …, 2014 - Springer
The goal of early autism screening is earlier treatment. We pilot-tested a 12-week, low-
intensity treatment with seven symptomatic infants ages 7–15 months. Parents mastered the …

Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life

A Estes, L Zwaigenbaum, H Gu, T St. John… - Journal of …, 2015 - Springer
Background To delineate the early progression of autism spectrum disorder (ASD)
symptoms, this study investigated developmental characteristics of infants at high familial …

The autism diagnostic observation schedule, toddler module: standardized severity scores

AN Esler, VH Bal, W Guthrie, A Wetherby… - Journal of autism and …, 2015 - Springer
Standardized calibrated severity scores (CSS) have been created for Autism Diagnostic
Observation Schedule, 2nd edition (ADOS-2) Modules 1–4 as a metric of the relative …

18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study

K Chawarska, F Shic, S Macari, DJ Campbell… - Journal of the American …, 2014 - Elsevier
Objective Younger siblings of children with autism spectrum disorder (ASD) are at high risk
(HR) for developing ASD as well as features of the broader autism phenotype. Although this …

Can parents' concerns predict autism spectrum disorder? A prospective study of high-risk siblings from 6 to 36 months of age

LAR Sacrey, L Zwaigenbaum, S Bryson, J Brian… - Journal of the American …, 2015 - Elsevier
Objective This prospective study characterized parents' concerns about infants at high risk
for developing autism spectrum disorder (ASD; each with an older sibling with ASD) at …