2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist

C McNamara, K Mankad, S Thust, L Dixon… - Neuroradiology, 2022 - Springer
The fifth edition of the World Health Organization Classification of Tumours of the Central
Nervous System (WHO CNS5) published in 2021 builds on the 2016 edition and …

A radiologist's guide to the 2021 WHO Central Nervous System Tumor Classification: part I—key concepts and the spectrum of diffuse gliomas

DR Johnson, C Giannini, RA Vaubel, JM Morris… - Radiology, 2022 - pubs.rsna.org
The fifth edition of the World Health Organization (WHO) classification of tumors of the
central nervous system, published in 2021, contains substantial updates in the classification …

Major changes in 2021 world health organization classification of central nervous system tumors

R Kurokawa, M Kurokawa, A Baba, Y Ota… - Radiographics, 2022 - pubs.rsna.org
The World Health Organization (WHO) published the fifth edition of the WHO Classification
of Tumors of the Central Nervous System (WHO CNS5) in 2021, as an update of the WHO …

Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study

AB Lassman, JM Sepúlveda-Sánchez… - Clinical Cancer …, 2022 - AACR
Purpose: FGFR genomic alterations (amplification, mutations, and/or fusions) occur in∼ 8%
of gliomas, particularly FGFR1 and FGFR3. We conducted a multicenter open-label, single …

Neuroimaging features of diffuse hemispheric glioma, H3 G34‐mutant: A case series and systematic review

R Kurokawa, A Baba, M Kurokawa… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Purpose Diffuse hemispheric gliomas, H3 G34‐mutant (DHGs‐
G34m), are newly recognized malignant brain tumors characterized by histone gene …

The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 2—Summary of Imaging Findings on Pediatric‐Type Diffuse High‐Grade …

YW Park, P Vollmuth, M Foltyn‐Dumitru… - Journal of Magnetic …, 2023 - Wiley Online Library
The fifth edition of the World Health Organization (WHO) classification of central nervous
system tumors published in 2021 advances the role of molecular diagnostics in the …

The prognostic significance of further genotyping H3G34 diffuse hemispheric gliomas

HG Vuong, HT Le, IF Dunn - Cancer, 2022 - Wiley Online Library
Background H3G34‐mutant diffuse hemispheric glioma (DHG) is recognized as a new,
distinct entity in the latest World Health Organization classification for central nervous system …

Imaging features associated with H3 K27-altered and H3 G34-mutant gliomas: a narrative systematic review

A Lasocki, G Abdalla, G Chow, SC Thust - Cancer Imaging, 2022 - Springer
Background Advances in molecular diagnostics accomplished the discovery of two
malignant glioma entities harboring alterations in the H3 histone: diffuse midline glioma, H3 …

[HTML][HTML] Development of immunotherapy for high-grade gliomas: Overcoming the immunosuppressive tumor microenvironment

A Franson, BL McClellan, ML Varela, A Comba… - Frontiers in …, 2022 - frontiersin.org
The preclinical and clinical development of novel immunotherapies for the treatment of
central nervous system (CNS) tumors is advancing at a rapid pace. High-grade gliomas …

[HTML][HTML] Adult type diffuse gliomas in the new 2021 WHO Classification

M Antonelli, PL Poliani - Pathologica, 2022 - ncbi.nlm.nih.gov
Adult-type diffuse gliomas represent a group of highly infiltrative central nervous system
tumors with a prognosis that significantly varies depending on the specific subtype and …