Hyperpolarized solution-state NMR spectroscopy with optically polarized crystals
TR Eichhorn, AJ Parker, F Josten… - Journal of the …, 2022 - ACS Publications
Nuclear spin hyperpolarization provides a promising route to overcome the challenges
imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that …
imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that …
Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications
BJ Tickner, VV Zhivonitko - Chemical Science, 2022 - pubs.rsc.org
Parahydrogen-induced polarisation (PHIP) is a nuclear spin hyperpolarisation technique
employed to enhance NMR signals for a wide range of molecules. This is achieved by …
employed to enhance NMR signals for a wide range of molecules. This is achieved by …
A versatile compact parahydrogen membrane reactor
Abstract We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous
parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the …
parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the …
Through-space multinuclear magnetic resonance signal enhancement induced by parahydrogen and radiofrequency amplification by stimulated emission of radiation
OG Salnikov, IA Trofimov, AN Pravdivtsev… - Analytical …, 2022 - ACS Publications
Hyperpolarized (ie, polarized far beyond the thermal equilibrium) nuclear spins can result in
the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here …
the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here …
RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction
The spatial resolution of magnetic resonance imaging (MRI) is limited by the width of
Lorentzian point spread functions associated with the transverse relaxation rate 1/T 2*. Here …
Lorentzian point spread functions associated with the transverse relaxation rate 1/T 2*. Here …
Spontaneous enhancement of magnetic resonance signals using a RASER
S Korchak, L Kaltschnee, R Dervisoglu… - Angewandte …, 2021 - Wiley Online Library
Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity:
Only a few spins contribute to the overall signal. To overcome this limitation …
Only a few spins contribute to the overall signal. To overcome this limitation …
Clinical-scale production of nearly pure (> 98.5%) parahydrogen and quantification by benchtop NMR spectroscopy
S Nantogma, B Joalland, K Wilkens… - Analytical …, 2021 - ACS Publications
Because of the extensive chemical, physical, and biomedical applications of parahydrogen,
the need exists for the development of highly enriched parahydrogen in a robust and …
the need exists for the development of highly enriched parahydrogen in a robust and …
Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation
Abstract The feasibility of Carbon‐13 Radiofrequency (RF) Amplification by Stimulated
Emission of Radiation (C‐13 RASER) is demonstrated on a bolus of liquid hyperpolarized …
Emission of Radiation (C‐13 RASER) is demonstrated on a bolus of liquid hyperpolarized …
Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-13C]Pyruvate
13C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular
events in cancer and other diseases with aberrant metabolic pathways. This metabolic …
events in cancer and other diseases with aberrant metabolic pathways. This metabolic …
Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation
B Joalland, T Theis, S Appelt… - Angewandte Chemie …, 2021 - Wiley Online Library
We report on the utility of Radiofrequency Amplification by Stimulated Emission Radiation
(RASER) for background‐free proton detection of hyperpolarized biomolecules. We …
(RASER) for background‐free proton detection of hyperpolarized biomolecules. We …