Nuclear spin hyperpolarization provides a promising route to overcome the challenges
imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that …

Parahydrogen-induced polarisation (PHIP) is a nuclear spin hyperpolarisation technique
employed to enhance NMR signals for a wide range of molecules. This is achieved by …

Abstract We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous
parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the …

Hyperpolarized (ie, polarized far beyond the thermal equilibrium) nuclear spins can result in
the radiofrequency amplification by stimulated emission of radiation (RASER) effect. Here …

The spatial resolution of magnetic resonance imaging (MRI) is limited by the width of
Lorentzian point spread functions associated with the transverse relaxation rate 1/T 2*. Here …

Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity:
Only a few spins contribute to the overall signal. To overcome this limitation …

Because of the extensive chemical, physical, and biomedical applications of parahydrogen,
the need exists for the development of highly enriched parahydrogen in a robust and …

Abstract The feasibility of Carbon‐13 Radiofrequency (RF) Amplification by Stimulated
Emission of Radiation (C‐13 RASER) is demonstrated on a bolus of liquid hyperpolarized …

13C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular
events in cancer and other diseases with aberrant metabolic pathways. This metabolic …

We report on the utility of Radiofrequency Amplification by Stimulated Emission Radiation
(RASER) for background‐free proton detection of hyperpolarized biomolecules. We …