Current methodologies to refine bioavailability, delivery, and therapeutic efficacy of plant flavonoids in cancer treatment
CG Vazhappilly, M Amararathna, AC Cyril… - The Journal of …, 2021 - Elsevier
Over the last two decades, several advancements have been made to improve the
therapeutic efficacy of plant flavonoids, especially in cancer treatment. Factors such as low …
therapeutic efficacy of plant flavonoids, especially in cancer treatment. Factors such as low …
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology
G Anderson - Biochemical pharmacology, 2019 - Elsevier
A plethora of factors contribute to the biochemical underpinnings of breast cancer, in the
absence of any clear, integrative framework. This article proposes that melatonergic …
absence of any clear, integrative framework. This article proposes that melatonergic …
Multifunctional silica-based nanoparticles with controlled release of organotin metallodrug for targeted theranosis of breast cancer
K Ovejero Paredes, D Díaz-García… - Cancers, 2020 - mdpi.com
Three different multifunctional nanosystems based on the tethering onto mesoporous silica
nanoparticles (MSN) of different fragments such as an organotin-based cytotoxic compound …
nanoparticles (MSN) of different fragments such as an organotin-based cytotoxic compound …
Repositioning Cannabinoids and Terpenes as Novel EGFR-TKIs Candidates for Targeted Therapy Against Cancer: A virtual screening model using CADD and …
This study examines the potential of Cannabis sativa L. plants to be repurposed as
therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor …
therapeutic agents for cancer treatment through designing of hybrid Epidermal growth factor …
Adenylyl cyclase type 8 overexpression impairs phosphorylation-dependent Orai1 inactivation and promotes migration in MDA-MB-231 breast cancer cells
J Sanchez-Collado, JJ Lopez, I Jardin, PJ Camello… - Cancers, 2019 - mdpi.com
Orai1 plays a major role in store-operated Ca2+ entry (SOCE) in triple-negative breast
cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein …
cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein …
The impact of CBP expression in estrogen receptor-positive breast cancer
Background The development of new biomarkers with diagnostic, prognostic and
therapeutic prominence will greatly enhance the management of breast cancer (BC) …
therapeutic prominence will greatly enhance the management of breast cancer (BC) …
Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
Background HER2 plays a critical role in tumourigenesis and is associated with poor
prognosis of patients with HER2-positive breast cancers. Although anti-HER2 drugs are …
prognosis of patients with HER2-positive breast cancers. Although anti-HER2 drugs are …
[HTML][HTML] Induction of DNA damage, apoptosis and cell cycle perturbation mediate cytotoxic activity of new 5-aminosalicylate–4-thiazolinone hybrid derivatives
Modulation of several targets in cancer cells enhances the effect of anti-cancer drugs. This
can be achieved by using combinations of anti-cancer drugs or by designing new drugs with …
can be achieved by using combinations of anti-cancer drugs or by designing new drugs with …
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress
EM De Francesco, F Cirillo, V Vella… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Triple-negative breast cancer (TNBC) is a heterogeneous disease
characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and …
characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and …
Epigenetics of triple-negative breast cancer via natural compounds
Triple-negative breast cancer (TNBC) is a highly resistant, lethal, and metastatic sub-division
of breast carcinoma, characterized by the deficiency of estrogen receptor (ER), progesterone …
of breast carcinoma, characterized by the deficiency of estrogen receptor (ER), progesterone …