The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Functional biomaterials for bone regeneration: a lesson in complex biology

AR Armiento, LP Hatt… - Advanced Functional …, 2020 - Wiley Online Library
Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …

Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Cell-scaffold interactions in the bone tissue engineering triad.

CM Murphy, F O'Brien, DG Little, A Schindeler - 2013 - repository.rcsi.com
Bone tissue engineering has emerged as one of the leading fields in tissue engineering and
regenerative medicine. The success of bone tissue engineering relies on understanding the …

Life in 3D is never flat: 3D models to optimise drug delivery

KA Fitzgerald, M Malhotra, CM Curtin, FJ O'Brien… - Journal of controlled …, 2015 - Elsevier
The development of safe, effective and patient-acceptable drug products is an expensive
and lengthy process and the risk of failure at different stages of the development life-cycle is …

Gene therapy approaches to regenerating the musculoskeletal system

CH Evans, J Huard - Nature Reviews Rheumatology, 2015 - nature.com
Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

[PDF][PDF] Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.

C Curtin, EG Tierney, K McSorley, SA Cryan, G Duffy… - 2015 - repository.rcsi.com
Vascularization and bone repair are accelerated by a series of gene-activated scaffolds
delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in …

Chitosan for gene delivery and orthopedic tissue engineering applications

R Raftery, FJ O'Brien, SA Cryan - Molecules, 2013 - mdpi.com
Gene therapy involves the introduction of foreign genetic material into cells in order exert a
therapeutic effect. The application of gene therapy to the field of orthopaedic tissue …

Articulation inspired by nature: a review of biomimetic and biologically active 3D printed scaffolds for cartilage tissue engineering

DG O'Shea, CM Curtin, FJ O'Brien - Biomaterials Science, 2022 - pubs.rsc.org
In the human body, articular cartilage facilitates the frictionless movement of synovial joints.
However, due to its avascular and aneural nature, it has a limited ability to self-repair when …

[HTML][HTML] Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix

Y Esmaeili, E Bidram, A Bigham, M Atari… - Alexandria Engineering …, 2023 - Elsevier
The advancement of tissue engineering for regenerating injured tissues and organs has
progressed significantly in recent years. Various techniques have been used to modify the …