Kinesin-2 was first purified as a heterotrimeric, anterograde, microtubule-based motor
consisting of two distinct kinesin-related subunits and a novel associated protein (KAP) that …

Axonal transport is the lifeline of axons and synapses. After synthesis in neuronal cell
bodies, proteins are conveyed into axons in two distinct rate classes—fast and slow axonal …

Highlights•Pulse-chase radiolabeling studies characterized fast and slow axonal
transport.•Fast and slow axonal transport conveys distinct, non-overlapping …

High concentration of cytoskeletal filaments, organelles, and proteins along with the space
constraints due to the axon's narrow geometry lead inevitably to intracellular physical …

Although it is known that cytosolic/soluble proteins synthesized in cell bodies are
transported at much lower overall velocities than vesicles in fast axonal transport, the …

Kinesin-driven organelle transport is crucial for neuron development and maintenance, yet
the mechanisms by which kinesins specifically bind their organelle cargoes remain …

Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of
intracellular movements. Regulation of Kinesin activity and Kinesin-cargo interactions …

The polarized morphology of neurons necessitates the delivery of proteins synthesized in
the soma along the length of the axon to distal synapses; critical for sustaining …

Local endosomal recycling at synapses is essential to maintain neurotransmission.
Rab4GTPase, found on sorting endosomes, is proposed to balance the flow of vesicles …

Synthesis and release of neurotransmitters such as acetylcholine (ACh) are key to synaptic
function. However, little is known about the spatial regulation of their synthesizing …