Kinesin-2: a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions
JM Scholey - Annual review of cell and developmental biology, 2013 - annualreviews.org
Kinesin-2 was first purified as a heterotrimeric, anterograde, microtubule-based motor
consisting of two distinct kinesin-related subunits and a novel associated protein (KAP) that …
consisting of two distinct kinesin-related subunits and a novel associated protein (KAP) that …
Seeing the unseen: the hidden world of slow axonal transport
S Roy - The Neuroscientist, 2014 - journals.sagepub.com
Axonal transport is the lifeline of axons and synapses. After synthesis in neuronal cell
bodies, proteins are conveyed into axons in two distinct rate classes—fast and slow axonal …
bodies, proteins are conveyed into axons in two distinct rate classes—fast and slow axonal …
Phosphoregulation of kinesins involved in long-range intracellular transport
D Kumari, K Ray - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of
intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions …
intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions …
Finding order in slow axonal transport
S Roy - Current opinion in neurobiology, 2020 - Elsevier
Highlights•Pulse-chase radiolabeling studies characterized fast and slow axonal
transport.•Fast and slow axonal transport conveys distinct, non-overlapping …
transport.•Fast and slow axonal transport conveys distinct, non-overlapping …
Fast vesicle transport is required for the slow axonal transport of synapsin
Although it is known that cytosolic/soluble proteins synthesized in cell bodies are
transported at much lower overall velocities than vesicles in fast axonal transport, the …
transported at much lower overall velocities than vesicles in fast axonal transport, the …
Crowd control: effects of physical crowding on cargo movement in healthy and diseased neurons
V Sabharwal, SP Koushika - Frontiers in cellular neuroscience, 2019 - frontiersin.org
High concentration of cytoskeletal filaments, organelles, and proteins along with the space
constraints due to the axon's narrow geometry lead inevitably to intracellular physical …
constraints due to the axon's narrow geometry lead inevitably to intracellular physical …
KAP is the neuronal organelle adaptor for Kinesin-2 KIF3AB and KIF3AC
A Garbouchian, AC Montgomery… - Molecular Biology of …, 2022 - Am Soc Cell Biol
Kinesin-driven organelle transport is crucial for neuron development and maintenance, yet
the mechanisms by which kinesins specifically bind their organelle cargoes remain …
the mechanisms by which kinesins specifically bind their organelle cargoes remain …
[HTML][HTML] Anterograde transport of Rab4-associated vesicles regulates synapse organization in Drosophila
Local endosomal recycling at synapses is essential to maintain neurotransmission.
Rab4GTPase, found on sorting endosomes, is proposed to balance the flow of vesicles …
Rab4GTPase, found on sorting endosomes, is proposed to balance the flow of vesicles …
BNIP-H recruits the cholinergic machinery to neurite terminals to promote acetylcholine signaling and neuritogenesis
J Sun, CQ Pan, TW Chew, F Liang, M Burmeister… - Developmental Cell, 2015 - cell.com
Synthesis and release of neurotransmitters such as acetylcholine (ACh) are key to synaptic
function. However, little is known about the spatial regulation of their synthesizing …
function. However, little is known about the spatial regulation of their synthesizing …
Imaging diversity in slow axonal transport
The polarized morphology of neurons necessitates the delivery of proteins synthesized in
the soma along the length of the axon to distal synapses; critical for sustaining …
the soma along the length of the axon to distal synapses; critical for sustaining …