Simple Summary Drug therapy is an important treatment for cancer patients; however, drug
resistance severely affects the survival time and quality of life of cancer patients. Oxidative …

The CRISPR genome editing technology has revolutionized the way gene function is
studied. Genome editing can be achieved in single genes or for thousands of genes …

Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However,
the therapeutic efficacy of existing metabolism‐regulating agents is often compromised due …

The activation of Homo sapiens Casein lysing protease P (HsClpP) by a chemical or genetic
strategy has been proved to be a new potential therapy in acute myeloid leukemia (AML) …

Inhibitors of dihydroorotate dehydrogenase (DHODH), a key enzyme for de novo synthesis
of pyrimidine nucleotides, have failed in clinical trials for various cancers despite robust …

Acute myeloid leukemia (AML) is a fatal disease characterized by the accumulation of
undifferentiated myeloblasts, and agents that promote differentiation have been effective in …

Leukemogenesis is a complex process that involves multiple stages of mutation in either
hematopoietic stem or progenitor cells, leading to cancer development over time. Acute …

Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) have a poor
prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets …

Acute myeloid leukemia (AML) leads to the accumulation of immature myeloid blasts in the
blood and bone marrow. It is the most common acute leukemia in adults and second most …