Glycans and glycoproteins as specific biomarkers for cancer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …
aspects of human growth and development. Defective glycosylation has adverse effects on …
Oligosaccharide analysis by mass spectrometry: a review of recent developments
Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …
A systematic approach to protein glycosylation analysis: a path through the maze
K Marino, J Bones, JJ Kattla, PM Rudd - Nature chemical biology, 2010 - nature.com
Protein glycosylation is an important post-translational modification. It is a feature that
enhances the functional diversity of proteins and influences their biological activity. A wide …
enhances the functional diversity of proteins and influences their biological activity. A wide …
High-sensitivity analytical approaches for the structural characterization of glycoproteins
1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
propensity to form varied linkages, substitutions, and branching patterns have fascinated …
High-mannose glycans are elevated during breast cancer progression
MLA De Leoz, LJT Young, HJ An… - Molecular & Cellular …, 2011 - ASBMB
Alteration in glycosylation has been observed in cancer. However, monitoring glycosylation
changes during breast cancer progression is difficult in humans. In this study, we used a well …
changes during breast cancer progression is difficult in humans. In this study, we used a well …
Glycomics and disease markers
HJ An, SR Kronewitter, MLA de Leoz… - Current opinion in …, 2009 - Elsevier
Glycomics is the comprehensive study of all glycans expressed in biological systems. The
biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl …
biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl …
Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures
DL Aldredge, MR Geronimo, S Hua, CC Nwosu… - …, 2013 - academic.oup.com
Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as
well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients …
well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients …
Comprehensive structural glycomic characterization of the glycocalyxes of cells and tissues
The glycocalyx comprises glycosylated proteins and lipids and fcorms the outermost layer of
cells. It is involved in fundamental inter-and intracellular processes, including non-self-cell …
cells. It is involved in fundamental inter-and intracellular processes, including non-self-cell …
Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association
The year 2014 marked the 20th anniversary of the coining of the term proteomics. The
purpose of this scientific statement is to summarize advances over this period that have …
purpose of this scientific statement is to summarize advances over this period that have …
Comparison of the human and bovine milk N-glycome via high-performance microfluidic chip liquid chromatography and tandem mass spectrometry
CC Nwosu, DL Aldredge, H Lee, LA Lerno… - Journal of proteome …, 2012 - ACS Publications
The isolation of whey proteins from human and bovine milks followed by profiling of their
entire N-glycan repertoire is described. Whey proteins resulting from centrifugation and …
entire N-glycan repertoire is described. Whey proteins resulting from centrifugation and …