Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS,
microglia play an important role in the monitoring and intervention of synaptic and neuron …

COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

For many years, modulators of the renin angiotensin system (RAS) have been trusted by
clinicians for the control of essential hypertension. It was recently demonstrated that these …

The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/
alternatively activated (M2) phenotypes following environmental signals related to …

Rationale: Neurogenic hypertension is characterized by an increase in sympathetic activity
and often resistance to drug treatments. We previously reported that it is also associated with …

Angiotensin II (AngII) is implicated in neuroinflammation, blood-brain barrier (BBB)
disruption, and autonomic dysfunction in hypertension. We have previously shown that …

Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Hypertension is a multifactorial disease. Although a number of different underlying
mechanisms have been learned from the various experimental models of the disease …