Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Interventions to address the US opioid crisis primarily target opioid use, misuse, and
addiction, but because the opioid crisis includes multiple substances, the opioid specificity of …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Opioid use disorder (OUD) is a chronic, relapsing condition, often associated with legal,
interpersonal, and employment problems. Medications demonstrated to be effective for OUD …

Public health authorities have described, with growing alarm, an unprecedented increase in
morbidity and mortality associated with use of opioid pain relievers (OPRs). Efforts to …

A life stage perspective is necessary for development of age-appropriate strategies to
address substance use disorders (SUDs) and related health conditions in order to produce …

Aims To review the literature on mortality among dependent or regular users of opioids
across regions, according to specific causes, and related to a number of demographic and …

Opioid addiction is associated with excess mortality, morbidities, and other adverse
conditions. Guided by a life-course framework, we review the literature on the long-term …

Illicit use of opiates is the fastest growing substance use problem in the United States, and
the main reason for seeking addiction treatment services for illicit drug use throughout the …

Aims To estimate the prevalence and burden of disease attributable to opioid dependence
globally, regionally and at country level. Methods Multiple search strategies:(i) peer …